Role of analgesic adjuncts in postoperative pain management

Anesthesiol Clin North Am. 2005 Mar;23(1):85-107. doi: 10.1016/j.atc.2004.11.007.


Postoperative pain remains a major problem. A multi-modal analgesic approach is recommended to optimize pain management and reduce opiate-related adverse effects. Several analgesic adjuncts have been investigated, and many have proved to have a useful analgesic effect. This article reviews the literature regarding use of analgesic adjuncts in the perioperative period.

Publication types

  • Review

MeSH terms

  • Adrenal Cortex Hormones / therapeutic use
  • Adrenergic alpha-2 Receptor Agonists
  • Analgesics / therapeutic use*
  • Anticonvulsants / therapeutic use
  • Excitatory Amino Acid Antagonists / therapeutic use
  • Humans
  • Narcotic Antagonists / therapeutic use
  • Pain, Postoperative / drug therapy*
  • Receptors, N-Methyl-D-Aspartate / antagonists & inhibitors


  • Adrenal Cortex Hormones
  • Adrenergic alpha-2 Receptor Agonists
  • Analgesics
  • Anticonvulsants
  • Excitatory Amino Acid Antagonists
  • Narcotic Antagonists
  • Receptors, N-Methyl-D-Aspartate