Prevalence, characteristics and natural course of inappropriate sinus tachycardia

Europace. 2005 Mar;7(2):104-12. doi: 10.1016/j.eupc.2004.12.007.


Aims: To study the prevalence, characteristics and natural course of inappropriate sinus tachycardia (IST).

Methods and results: The prevalence and characteristics of IST were evaluated in a random sample of 604 middle-aged subjects. Seven of the subjects (1.16%) fulfilled the contemporary diagnostic criteria of IST. The systolic (147+/-11 mmHg vs. 130+/-13 mmHg, P<0.001) and diastolic ambulatory blood pressures (92+/-7 mmHg vs. 81+/-8 mmHg, P<0.001) were higher among the subjects with IST than among the controls. The other laboratory, echocardiographic and personality measurements, with the exception of the hostility score (10+/-2 vs. 8+/-3, P<0.001), revealed no differences between the groups. The natural course and prognosis of the disorder was assessed among the subjects fulfilling the IST criteria and nine previously diagnosed IST patients. During a mean follow-up of 6.0+/-2.4 years, none of the subjects developed any clinical or echocardiographic evidence of structural heart disease despite ongoing palpitations, and there was no significant reduction in the 24-h average HR (9+/-2 bpm vs. 89+/-8 bpm, P=0.204).

Conclusion: The prevalence of IST in a middle-aged population was higher than previously assumed. Despite the chronic nature of the disorder, the prognosis of IST was benign. The causal relationship between IST and hypertension and/or hostile personality type remains speculative.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Chi-Square Distribution
  • Female
  • Finland / epidemiology
  • Heart Rate / physiology
  • Humans
  • Male
  • Middle Aged
  • Prevalence
  • Prognosis
  • Statistics, Nonparametric
  • Tachycardia, Sinus / epidemiology*
  • Tachycardia, Sinus / physiopathology*