Supplementation with Evelle improves skin smoothness and elasticity in a double-blind, placebo-controlled study with 62 women

J Dermatolog Treat. 2004 Jul;15(4):222-6. doi: 10.1080/09546630410033772.


Objective: To investigate whether nutritional intervention with a proprietary formulation and other micronutrients may favourably alter skin roughness and elasticity.

Methods: Sixty-two women aged 45-73 years participated in a double-blind, placebo-controlled trial testing the efficacy of a proprietary oral supplement for skin nutrition (Evelle), for improvement of skin elasticity and roughness. The active ingredients were vitamins C and E, carotenoids, selenium, zinc, amino acids and glycosaminoglycans, blueberry extract and Pycnogenol.

Results: Skin elasticity, measured using an optical cutometer, was found to be statistically significantly increased by 9% after 6 weeks of treatment compared with placebo (p=0.0351). Skin roughness, as evaluated by three-dimensional microtopography imaging, was found to be statistically significantly lowered by 6% compared with the control group after 12 weeks treatment (p=0.0157).

Conclusion: Evelle can potentially improve visible signs of cutaneous ageing.

Publication types

  • Clinical Trial
  • Randomized Controlled Trial

MeSH terms

  • Aged
  • Dietary Supplements*
  • Double-Blind Method
  • Elasticity
  • Flavonoids / administration & dosage*
  • Humans
  • Micronutrients / administration & dosage*
  • Middle Aged
  • Plant Extracts
  • Skin Aging / drug effects*
  • Skin Physiological Phenomena / drug effects
  • Tablets


  • Flavonoids
  • Micronutrients
  • Plant Extracts
  • Tablets
  • pycnogenols