Rosai-Dorfman disease recurrence with bilateral orbital masses following immunosuppressant therapy

Orbit. 2005 Mar;24(1):51-3. doi: 10.1080/01676830590897209.

Abstract

Rosai-Dorfman disease is a rare condition characterised by massive lymphadenopathy involving the orbit in 11% of cases. Immunohistochemical analysis remains key to the diagnosis with characteristic immunohistochemical S100 staining of histiocytes and lymphocyte phagocytosis. We report the case of a 43-year-old female with recurrence of bilateral orbital Rosai-Dorfman disease following long-term immunosuppressant therapy. Long-term follow-up is advised in conservatively managed patients and surgery may offer more definitive treatment.

Publication types

  • Case Reports

MeSH terms

  • Adult
  • Anemia, Hemolytic, Autoimmune / diagnosis
  • Anemia, Hemolytic, Autoimmune / drug therapy*
  • Biopsy, Needle
  • Dose-Response Relationship, Drug
  • Female
  • Follow-Up Studies
  • Histiocytosis, Sinus / chemically induced*
  • Histiocytosis, Sinus / pathology
  • Histiocytosis, Sinus / surgery*
  • Humans
  • Immunohistochemistry
  • Immunosuppressive Agents / adverse effects
  • Immunosuppressive Agents / therapeutic use
  • Orbital Diseases / chemically induced*
  • Orbital Diseases / pathology
  • Orbital Diseases / surgery*
  • Prednisolone / adverse effects*
  • Prednisolone / therapeutic use
  • Recurrence
  • Risk Assessment
  • Time Factors
  • Treatment Outcome

Substances

  • Immunosuppressive Agents
  • Prednisolone