Serum insulin-like growth factor-1 is an independent predictor of prognosis in patients with renal cell carcinoma

Acta Oncol. 2004;43(8):744-8. doi: 10.1080/02841860410017260.


Obesity is associated with an increased risk of certain cancers, including renal cell carcinoma. A possible mediator of this risk is insulin-like growth factor-1 (IGF-1). The authors evaluated the prognostic information of IGF-1, IGFBP-3, leptin, and prealbumin in sera sampled at diagnosis from 256 consecutive patients with renal cell carcinoma. Insulin-like growth factor-1 and leptin were positively correlated to body mass index (BMI). Insulin-like growth factor-1 and IGFBP-3 did not correlate to tumour stage or grade. Leptin and prealbumin were both inversely related to tumour stage and grade. When survival was analysed in patients with levels above a median of IGF-1, leptin, and prealbumin, prognosis was more favourable, compared with those with lower levels (p=0.017; p=0.024, and p<0.0001, respectively). In a multivariate analysis, tumour stage and serum IGF-1 levels were independent prognostic factors. The results indicate that serum IGF-1 at diagnosis is related to prognosis in renal cell carcinoma.

Publication types

  • Comparative Study
  • Research Support, Non-U.S. Gov't

MeSH terms

  • Adult
  • Age Factors
  • Aged
  • Aged, 80 and over
  • Biomarkers, Tumor / blood*
  • Biopsy, Needle
  • Carcinoma, Renal Cell / diagnosis*
  • Carcinoma, Renal Cell / mortality*
  • Carcinoma, Renal Cell / therapy
  • Cohort Studies
  • Female
  • Humans
  • Immunohistochemistry
  • Insulin-Like Growth Factor I / analysis
  • Insulin-Like Growth Factor I / metabolism*
  • Kidney Neoplasms / diagnosis*
  • Kidney Neoplasms / mortality*
  • Kidney Neoplasms / therapy
  • Male
  • Middle Aged
  • Multivariate Analysis
  • Neoplasm Staging
  • Predictive Value of Tests
  • Prognosis
  • Proportional Hazards Models
  • Retrospective Studies
  • Risk Assessment
  • Sensitivity and Specificity
  • Sex Factors
  • Statistics, Nonparametric
  • Survival Analysis


  • Biomarkers, Tumor
  • Insulin-Like Growth Factor I