Death ligand-mediated apoptosis in HIV infection

Rev Med Virol. May-Jun 2005;15(3):169-78. doi: 10.1002/rmv.462.

Abstract

Apoptosis has been suggested to cause severe CD4+ T cell depletion in patients infected with HIV. This review focuses on the biological events involved in death ligand-induced apoptosis during HIV infection. Among these ligands, TRAIL appears critical in HIV-infection. Death ligand-induced apoptosis might be a major pathogenic event in many virus-induced diseases including AIDS and the clarification of its mechanism will aid in the development of therapeutic strategies.

Publication types

  • Research Support, Non-U.S. Gov't
  • Review

MeSH terms

  • Apoptosis Regulatory Proteins
  • Apoptosis*
  • Carrier Proteins / physiology
  • Cytokine TWEAK
  • Fas Ligand Protein
  • HIV / physiology*
  • HIV Infections / physiopathology*
  • HIV Infections / virology
  • Humans
  • Ligands
  • Membrane Glycoproteins / physiology*
  • T-Lymphocytes / physiology*
  • T-Lymphocytes / virology
  • TNF-Related Apoptosis-Inducing Ligand
  • Tumor Necrosis Factor-alpha / physiology*
  • Tumor Necrosis Factors

Substances

  • Apoptosis Regulatory Proteins
  • Carrier Proteins
  • Cytokine TWEAK
  • FASLG protein, human
  • Fas Ligand Protein
  • Ligands
  • Membrane Glycoproteins
  • TNF-Related Apoptosis-Inducing Ligand
  • TNFSF10 protein, human
  • TNFSF12 protein, human
  • Tumor Necrosis Factor-alpha
  • Tumor Necrosis Factors