High antimicrobial activity apiphytopreparation in the form of the ointments containing pine turpentine, different concentration of propolis (from 4 to 20 %), honey and carotene oil from carrots (ointment N 4) has been. While testing by the method of diffusion in agar all the studied apiphytopreparation suppressed growth of Staphylococcus aureus, Bacillus subtilis, Saccharomyces cerevisiae, Micrococcus luteus, M. roseus. This effect increased with propolis content increase in the content of ointments. Bee honey and carotene oil intensified their antimicrobial activity. The latter was caused by the action of phenolic compounds, ether oils and other biologically active substances--the apiculture and vegetative raw material.