A/J mouse as a model for lung tumorigenesis caused by tobacco smoke: strengths and weaknesses

Exp Lung Res. Jan-Feb 2005;31(1):3-18. doi: 10.1080/01902140490494959.

Abstract

Strain A/J mice have successfully been used to develop an animal model for tobacco smoke carcinogenesis. In 18 individual studies, reported by 4 different laboratories, a significant increase in lung tumor multiplicities following exposure from 50 to 170mg/m3 of total suspended tobacco smoke particulates was found in 15 studies (83 %) and a significant increase in lung tumor incidence in 10 studies (56%). However, tumor multiplicities are comparatively low (from an average of 1.1 to 2.8 tumors per lung). From a toxicological standpoint, this indicates that cigarette smoke is a weak animal carcinogen. Although the assay allowed one to detect substantial chemopreventive activity of a mixture of myo-inositol and dexamethasone, it was less successful in showing efficacy for several other agents.

Publication types

  • Research Support, Non-U.S. Gov't
  • Research Support, U.S. Gov't, P.H.S.
  • Review

MeSH terms

  • Adenocarcinoma / etiology*
  • Adenocarcinoma / pathology
  • Adenocarcinoma / prevention & control
  • Animals
  • Carcinogens / adverse effects*
  • Chemoprevention
  • Disease Models, Animal*
  • Dose-Response Relationship, Drug
  • Inhalation Exposure
  • Lung Neoplasms / etiology*
  • Lung Neoplasms / pathology
  • Lung Neoplasms / prevention & control
  • Mice
  • Mice, Inbred A
  • Tobacco Smoke Pollution / adverse effects*

Substances

  • Carcinogens
  • Tobacco Smoke Pollution