Influence of three-day antimicrobial therapy and lactobacillus vaginal suppositories on recurrence of urinary tract infections

Clin Ther. Jan-Feb 1992;14(1):11-6.

Abstract

Forty-one adult women with acute lower urinary tract infections (UTI) were randomly treated for three days with norfloxacin or trimethoprim/sulfamethoxazole (TMP/SMX). Infection was eradicated in 100% of norfloxacin-treated patients and in 95% of TMP/SMX-treated patients. UTI recurred in 29% of patients treated with norfloxacin and in 41% of those treated with TMP/SMX. Post-therapy vaginal administration of lactobacillus suppositories resulted in a recurrence rate of UTI of only 21%, while in patients given sterilized skim-milk suppositories the recurrence rate was 47%. This study indicates that lactobacillus vaginal suppositories are safe and may be effective in reducing the recurrence of UTI following antimicrobial therapy.

Publication types

  • Clinical Trial
  • Randomized Controlled Trial
  • Research Support, Non-U.S. Gov't

MeSH terms

  • Adult
  • Enterobacteriaceae
  • Enterobacteriaceae Infections / drug therapy*
  • Escherichia coli
  • Escherichia coli Infections / drug therapy
  • Female
  • Humans
  • Klebsiella
  • Klebsiella Infections / drug therapy
  • Lactobacillus*
  • Norfloxacin / therapeutic use
  • Pessaries*
  • Proteus
  • Proteus Infections / drug therapy
  • Staphylococcal Infections / drug therapy
  • Staphylococcus
  • Trimethoprim, Sulfamethoxazole Drug Combination / therapeutic use
  • Urinary Tract Infections / drug therapy*
  • Urinary Tract Infections / microbiology

Substances

  • Trimethoprim, Sulfamethoxazole Drug Combination
  • Norfloxacin