Polymorphisms of interferon-inducible genes OAS-1 and MxA associated with SARS in the Vietnamese population

Biochem Biophys Res Commun. 2005 Apr 22;329(4):1234-9. doi: 10.1016/j.bbrc.2005.02.101.


We hypothesized that host antiviral genes induced by type I interferons might affect the natural course of severe acute respiratory syndrome (SARS). We analyzed single nucleotide polymorphisms (SNPs) of 2',5'-oligoadenylate synthetase 1 (OAS-1), myxovirus resistance-A (MxA), and double-stranded RNA-dependent protein kinase in 44 Vietnamese SARS patients with 103 controls. The G-allele of non-synonymous A/G SNP in exon 3 of OAS-1 gene showed association with SARS (p=0.0090). The G-allele in exon 3 of OAS-1 and the one in exon 6 were in strong linkage disequilibrium and both of them were associated with SARS infection. The GG genotype and G-allele of G/T SNP at position -88 in the MxA gene promoter were found more frequently in hypoxemic group than in non-hypoxemic group of SARS (p=0.0195). Our findings suggest that polymorphisms of two IFN-inducible genes OAS-1 and MxA might affect susceptibility to the disease and progression of SARS at each level.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • 2',5'-Oligoadenylate Synthetase / genetics*
  • Adolescent
  • Adult
  • Aged
  • Female
  • GTP-Binding Proteins / genetics*
  • Gene Frequency
  • Genetic Predisposition to Disease / genetics
  • Genotype
  • Humans
  • Male
  • Middle Aged
  • Myxovirus Resistance Proteins
  • Polymorphism, Genetic / genetics*
  • Severe Acute Respiratory Syndrome / genetics*
  • Vietnam


  • MX1 protein, human
  • Myxovirus Resistance Proteins
  • OAS1 protein, human
  • 2',5'-Oligoadenylate Synthetase
  • GTP-Binding Proteins