Improved picture naming in chronic aphasia after TMS to part of right Broca's area: an open-protocol study

Brain Lang. 2005 Apr;93(1):95-105. doi: 10.1016/j.bandl.2004.08.004.


Functional imaging studies with nonfluent aphasia patients have observed "over-activation" in right (R) language homologues. This may represent a maladaptive strategy; suppression may result in language improvement. We applied slow, 1 Hz repetitive transcranial magnetic stimulation (rTMS) to an anterior portion of R Broca's homologue daily, for 10 days in four aphasia patients who were 5-11 years poststroke. Significant improvement was observed in picture naming at 2 months post-rTMS, with lasting benefit at 8 months in three patients. This preliminary, open trial suggests that rTMS may provide a novel treatment approach for aphasia by possibly modulating the distributed, bi-hemispheric language network.

Publication types

  • Clinical Trial
  • Research Support, U.S. Gov't, Non-P.H.S.
  • Research Support, U.S. Gov't, P.H.S.

MeSH terms

  • Aphasia / physiopathology
  • Aphasia / rehabilitation*
  • Aphasia / therapy
  • Chronic Disease
  • Electric Stimulation Therapy*
  • Female
  • Frontal Lobe / physiology*
  • Functional Laterality / physiology*
  • Humans
  • Magnetics*
  • Male
  • Middle Aged
  • Pattern Recognition, Visual
  • Semantics
  • Treatment Outcome