Striational antibodies in myasthenia gravis: reactivity and possible clinical significance

Arch Neurol. 2005 Mar;62(3):442-6. doi: 10.1001/archneur.62.3.442.


Myasthenia gravis is an autoimmune disease caused, in most cases, by antibodies attaching to the acetylcholine receptor. Some myasthenia gravis patients have antibodies that bind in a cross-striational pattern to skeletal and heart muscle tissue sections (striational antibodies). These antibodies react with epitopes on the muscle proteins titin and ryanodine receptor, are found mainly in sera of patients with thymoma and late-onset myasthenia gravis, and may correlate with myasthenia gravis severity. Their presence may predict an unsatisfactory outcome after thymectomy. The detection of titin and ryanodine receptor antibodies provides more specific clinical information than the immunofluorescent demonstration of striational antibodies.

Publication types

  • Research Support, Non-U.S. Gov't
  • Review

MeSH terms

  • Autoantibodies / metabolism*
  • Binding Sites, Antibody*
  • Connectin
  • Humans
  • Microscopy, Fluorescence
  • Muscle Proteins / immunology
  • Muscle Proteins / metabolism
  • Muscle, Skeletal / immunology*
  • Muscle, Skeletal / pathology
  • Myasthenia Gravis / immunology*
  • Myasthenia Gravis / pathology
  • Protein Kinases / immunology
  • Protein Kinases / metabolism
  • Ryanodine Receptor Calcium Release Channel / immunology
  • Ryanodine Receptor Calcium Release Channel / metabolism


  • Autoantibodies
  • Connectin
  • Muscle Proteins
  • Ryanodine Receptor Calcium Release Channel
  • TTN protein, human
  • Protein Kinases