New insights on non-enzymatic glycosylation may lead to therapeutic approaches for the prevention of diabetic complications

Diabet Med. 1992 Apr;9(3):297-9. doi: 10.1111/j.1464-5491.1992.tb01783.x.


It is generally accepted that chronic hyperglycaemia is responsible for most of the long-term complications of diabetes. Several studies suggest that accelerated non-enzymatic glycosylation may be the underlying mechanism by which hyperglycaemia causes complications. More recently, glucose auto-oxidation has been linked to non-enzymatic glycosylation, and glycosylated proteins have been shown to be a source of free radicals. These findings suggest the possibility that oxidative stress may be related to the development of diabetic complications. Anti-oxidants such as vitamins C and E have recently been demonstrated to reduce protein glycosylation both in vivo and in vitro. In addition they also act as scavengers of free radicals generated by non-enzymatic glycosylation of protein. These findings may lead to new therapeutic approaches for the prevention of complications by limiting the damage caused by non-enzymatic glycosylation and oxidant stress. Such therapies may also be useful in complementing existing treatment in those with the long-term complications of diabetes.

Publication types

  • Review

MeSH terms

  • Antioxidants / pharmacology
  • Antioxidants / therapeutic use*
  • Diabetes Complications
  • Diabetes Mellitus / physiopathology*
  • Glycoproteins / metabolism
  • Glycosylation
  • Humans
  • Hyperglycemia / complications*


  • Antioxidants
  • Glycoproteins