Transforming growth factor -beta receptor signaling in cancer

Front Biosci. 2005 May 1;10:1135-45. doi: 10.2741/1606.


Transforming growth factor-beta (TGF-beta) is an ubiquitous cytokine that affects various biological processes, such as regulation of cell proliferation, immune responses, growth, differentiation, angiogenesis, and apoptosis of various cell types. The TGF-beta ligand initiates signaling by binding to and joining type I and II receptors of serine/threonine kinases. This review discusses the TGF-beta ligands and receptors, its positive and negative regulators in signaling, as well as its important roles with respect to tumor suppression and progression.

Publication types

  • Review

MeSH terms

  • Animals
  • Disease Progression
  • Humans
  • Neoplasms / metabolism*
  • Neoplasms / pathology
  • Proteasome Endopeptidase Complex / physiology
  • Receptors, Transforming Growth Factor beta / physiology*
  • Signal Transduction / physiology*
  • Smad Proteins / physiology
  • Transforming Growth Factor beta / physiology*


  • Receptors, Transforming Growth Factor beta
  • Smad Proteins
  • Transforming Growth Factor beta
  • Proteasome Endopeptidase Complex