The effects of hemodialysis and peritoneal dialysis on serum homocysteine and C-reactive protein levels

Mediators Inflamm. 2004 Dec;13(5-6):361-4. doi: 10.1080/09629350400008786.

Abstract

Objectives: In this study, we aimed to investigate plasma homocysteine (Hcy) and serum C-reactive protein (CRP) levels in hemodialysis (HD) and continuous ambulatory peritoneal dialysis (CAPD) patients, and the relation among them.

Materials and methods: This study was carriedout on 52 HD patients, 26 CAPD patients and a control group of 22 healthy persons. Blood samples were taken from the patients for Hcy and CRP measurements.

Results: Serum CRP level was found to be high in 48.1% of HD patients, 69.2% of CAPD patients and 4.5% of the healthy control group. Plasma Hcy level was found out to be above the normal limits in 73.1% of HD patients, 65.4% of CAPD patients and 9% of the healthy control group. There was a significant positive relation (r = 0.384, p < 0.001) between the levels of plasma Hcy and serum CRP in HD and CAPD patients.

Conclusion: The high levels of Hcy and CRP were found out to be higher in HD and CAPD patients than in the control group. In order to determine the risk rate of Hcy and CRP for coronary artery disease, extensive investigations are required in patients with chronic renal failure that also have coronary artery disease.

MeSH terms

  • Adult
  • C-Reactive Protein / metabolism*
  • Case-Control Studies
  • Coronary Artery Disease / blood
  • Coronary Artery Disease / etiology
  • Female
  • Homocysteine / blood*
  • Humans
  • Kidney Failure, Chronic / blood*
  • Kidney Failure, Chronic / complications
  • Kidney Failure, Chronic / therapy*
  • Male
  • Middle Aged
  • Peritoneal Dialysis, Continuous Ambulatory*
  • Renal Dialysis*
  • Risk Factors

Substances

  • Homocysteine
  • C-Reactive Protein