Taking account of the high specificity of the organic load of winery effluents, a new biophysical treatment using the stripping of ethanol combined with a final concentration by evaporation has been studied. Two options are proposed: full treatment and pre-treatment. The study of the composition of winery wastewater has shown the large, dominant part of ethanol in the organic load (75 to 99% of the COD). According to a linear correlation between COD and ethanol concentration, the determination of ethanol concentration can be used to estimate the organic load of winery wastewater. Full treatment by stripping and concentration at a pilot plant allows the separation of the wastewater into highly purified water (COD elimination > 99%), a concentrated alcoholic solution usable as bio-fuel and a concentrated by-product. Stripping alone represents an advantageous pre-treatment of winery wastewater. The purification rate reaches 78 to 85% and ethanol is recovered. The process facilitates discharge into a sewage system in view of treatment with domestic effluents and can also improve the efficiency of overloaded or old purification plants. The economical approach of this method demonstrates its competitiveness in comparison with biological treatments: low energy consumed, no sludge.