Highly efficient copper-catalyzed nitro-Mannich type reaction: cross-dehydrogenative-coupling between sp3 C-H bond and sp3 C-H bond

Zhiping Li; Chao-Jun Li

doi:10.1021/ja050058j

Highly efficient copper-catalyzed nitro-Mannich type reaction: cross-dehydrogenative-coupling between sp3 C-H bond and sp3 C-H bond

J Am Chem Soc. 2005 Mar 23;127(11):3672-3. doi: 10.1021/ja050058j.

Authors

Zhiping Li¹, Chao-Jun Li

Affiliation

¹ Department of Chemistry, McGill University, 801 Sherbrooke Street West, Montreal, Quebec H3A 2K6, Canada.

PMID: 15771482
DOI: 10.1021/ja050058j

Abstract

A novel C-C bond formation method was developed via the cross-dehydrogenative-coupling (CDC) reaction catalyzed by using copper bromide in the presence of an oxidizing reagent, tert-BuOOH. The CDC reaction provides a simple and efficient catalytic method to construct beta-nitroamine via the reaction between sp3 C-H and sp3 C-H bonds.