NK cell recognition

Annu Rev Immunol. 2005;23:225-74. doi: 10.1146/annurev.immunol.23.021704.115526.

Abstract

The integrated processing of signals transduced by activating and inhibitory cell surface receptors regulates NK cell effector functions. Here, I review the structure, function, and ligand specificity of the receptors responsible for NK cell recognition.

Publication types

  • Research Support, N.I.H., Extramural
  • Research Support, U.S. Gov't, P.H.S.
  • Review

MeSH terms

  • Animals
  • Histocompatibility Antigens Class I / metabolism
  • Humans
  • Immunity, Innate
  • Killer Cells, Natural / immunology*
  • Ligands
  • Mice
  • Models, Immunological
  • Receptors, Immunologic / chemistry
  • Receptors, Immunologic / genetics
  • Receptors, Immunologic / metabolism
  • Signal Transduction

Substances

  • Histocompatibility Antigens Class I
  • Ligands
  • Receptors, Immunologic