Isolation and primary structure of a novel chromogranin A-derived peptide, WE-14, from a human midgut carcinoid tumour

FEBS Lett. 1992 Apr 27;301(3):319-21. doi: 10.1016/0014-5793(92)80266-j.


The primary structure of a novel human chromogranin A-derived tetradecapeptide, WE-14, possessing N-terminal tryptophanyl (W) and C-terminal glutamyl (E) residues was isolated from a hepatic metastasis of an human ileal carcinoid tumour. Human and bovine WE-14 are structurally identical, while rat, mouse and porcine analogues exhibit 93% homology. WE-14 is flanked by paired basic residues (KR) in all known chromogranin A sequences.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Amino Acid Sequence
  • Carcinoid Tumor / metabolism*
  • Carcinoid Tumor / pathology
  • Chromatography, Gel
  • Chromatography, High Pressure Liquid
  • Chromogranin A
  • Chromogranins / metabolism*
  • Humans
  • Intestinal Neoplasms / metabolism*
  • Intestinal Neoplasms / pathology
  • Liver Neoplasms / metabolism
  • Liver Neoplasms / secondary
  • Male
  • Middle Aged
  • Molecular Sequence Data
  • Neoplasm Proteins / genetics*
  • Neoplasm Proteins / isolation & purification
  • Protein Processing, Post-Translational
  • Radioimmunoassay


  • CHGA protein, human
  • Chromogranin A
  • Chromogranins
  • Neoplasm Proteins
  • chromogranin A, mouse
  • chromogranin A, rat
  • chromogranin A-derived peptide, WE-14