Clerodane diterpenoids from Pulicaria wightiana

Biswanath Das; M Ravinder Reddy; R Ramu; N Ravindranath; H Harish; K V S Ramakrishna; Y Koteswar Rao; K Harakishore; U S N Murthy

doi:10.1016/j.phytochem.2005.02.004

Clerodane diterpenoids from Pulicaria wightiana

Phytochemistry. 2005 Mar;66(6):633-8. doi: 10.1016/j.phytochem.2005.02.004.

Authors

Biswanath Das¹, M Ravinder Reddy, R Ramu, N Ravindranath, H Harish, K V S Ramakrishna, Y Koteswar Rao, K Harakishore, U S N Murthy

Affiliation

¹ Indian Institute of Chemical Technology, Organic Chemistry-1, Tarnaka, Hyderabad 500 007, India. biswanthdas@yahoo.com

PMID: 15771881
DOI: 10.1016/j.phytochem.2005.02.004

Abstract

Five clerodane diterpenoids have been isolated from the aerial parts of Pulicaria wightiana along with 3'5,6-trihydroxy-3,4',7-trimethoxyflavone and 2-methyl-5-hydroxy-chroman-4-one. The structures and stereochemistry of the compounds were established from spectral (mainly 1D and 2D NMR) studies. The last two compounds were not reported earlier from this plant. The antibacterial activity of the diterpenoids were studied.

MeSH terms

Anti-Bacterial Agents / chemistry
Anti-Bacterial Agents / isolation & purification
Anti-Bacterial Agents / pharmacology
Asteraceae / chemistry*
Bacteria / drug effects
Chromans / isolation & purification
Diterpenes, Clerodane / chemistry
Diterpenes, Clerodane / isolation & purification*
Diterpenes, Clerodane / pharmacology
Flavones / isolation & purification
Molecular Structure

Substances

2-methyl-5-hydroxy-chroman-4-one
3',5,6-trihydroxy-3,4',7-trimethoxyflavone
Anti-Bacterial Agents
Chromans
Diterpenes, Clerodane
Flavones