SGK1: a rapid aldosterone-induced regulator of renal sodium reabsorption

Physiology (Bethesda). 2005 Apr;20:134-9. doi: 10.1152/physiol.00053.2004.


Recently, substantial progress has been made in understanding the mechanisms by which aldosterone rapidly stimulates sodium transport in the distal nephron and other tight epithelia. Serum- and glucocorticoid-regulated kinase 1 (SGK1) has been identified as an important mediator of this process. Its physiological relevance has been revealed through heterologous expression in cultured cells and generation of SGK1 knockout mice.

Publication types

  • Review

MeSH terms

  • Aldosterone / metabolism*
  • Animals
  • Epithelial Sodium Channels
  • Humans
  • Immediate-Early Proteins
  • Kidney / metabolism*
  • Nuclear Proteins / metabolism*
  • Protein-Serine-Threonine Kinases / metabolism*
  • Sodium / metabolism*
  • Sodium Channels / metabolism


  • Epithelial Sodium Channels
  • Immediate-Early Proteins
  • Nuclear Proteins
  • Sodium Channels
  • Aldosterone
  • Sodium
  • Protein-Serine-Threonine Kinases
  • serum-glucocorticoid regulated kinase