Comparison of cerebral blood flow between perfusion computed tomography and xenon-enhanced computed tomography for normal subjects: territorial analysis

J Comput Assist Tomogr. Mar-Apr 2005;29(2):270-7. doi: 10.1097/01.rct.0000156400.40836.68.


Objective: The purpose of this study was to clarify the difference between cerebral blood flow (CBF) by perfusion computed tomography (CT) and that by xenon-enhanced CT (Xe-CT) through simultaneous measurement.

Methods: Xenon-enhanced CT and perfusion CT were continually performed on 7 normal subjects. Ratios of CBF by perfusion CT (P-CBF) to CBF by Xe-CT (Xe-CBF) were measured for 5 arterial territories; 3 were territories of 3 major arteries (the anterior [ACA], middle [MCA], and posterior [PCA] cerebral arteries), and the other 2 were areas of the thalamus and putamen.

Results: The ratios were 1.30 +/- 0.10, 1.26 +/- 0.15, 1.61 +/- 0.15, 0.801 +/- 0.087, and 0.798 +/- 0.080 for the ACA, MCA, PCA, thalamus, and putamen, respectively. Although a good correlation was observed between P-CBF and Xe-CBF for each territory, the ratios were significantly different (P < 0.0001) between 3 territory groups (group 1: ACA and MCA, group 2: PCA, and group 3: thalamus and putamen).

Conclusions: The difference in the ratio of P-CBF to Xe-CBF between the 3 territory groups was considered to result principally from the features of P-CBF. To evaluate P-CBF properly, its territorial characteristics should be taken into account.

Publication types

  • Comparative Study

MeSH terms

  • Adult
  • Aged
  • Basal Ganglia / blood supply
  • Blood Flow Velocity / physiology
  • Brain / blood supply*
  • Cerebral Angiography*
  • Cerebral Arteries / diagnostic imaging
  • Contrast Media*
  • Cranial Sinuses / diagnostic imaging
  • Female
  • Headache / diagnostic imaging
  • Humans
  • Image Enhancement*
  • Image Processing, Computer-Assisted*
  • Intracranial Aneurysm / diagnostic imaging
  • Male
  • Middle Aged
  • Putamen / blood supply
  • Regional Blood Flow / physiology
  • Sensitivity and Specificity
  • Thalamus / blood supply
  • Tomography, X-Ray Computed*
  • Vertigo / diagnostic imaging
  • Xenon*


  • Contrast Media
  • Xenon