Increased frequency of sister chromatid exchanges in peripheral lymphocytes of alcoholics and cigarette smokers

Meral Yirmibeş Karaoğuz; Behçet Coşar; Zehra Arikan; Feride Başaran; Adnan Menevşe; Sevda Menevşe

doi:10.1016/j.cellbi.2004.11.019

Increased frequency of sister chromatid exchanges in peripheral lymphocytes of alcoholics and cigarette smokers

Cell Biol Int. 2005 Feb;29(2):165-8. doi: 10.1016/j.cellbi.2004.11.019. Epub 2005 Jan 16.

Authors

Meral Yirmibeş Karaoğuz¹, Behçet Coşar, Zehra Arikan, Feride Başaran, Adnan Menevşe, Sevda Menevşe

Affiliation

¹ Department of Medical Genetics, Gazi University School of Medicine, Besevler, 06500 Ankara, Turkey. karaoguz@gazi.edu.tr

PMID: 15774315
DOI: 10.1016/j.cellbi.2004.11.019

Abstract

Sister chromatid exchange (SCE) is a sensitive indicator of genotoxicity. In this study we investigated the effects of alcohol consumption and cigarette smoking on the frequency of SCE in cultures of peripheral lymphocytes. The rate was higher in alcoholics who smoked (10.89+/-2.46) and in smokers (positive controls) (7.64+/-1.01) than in healthy non-smokers (negative controls) (6.96+/-2.18). Statistical analysis suggested that the increases were related to alcohol consumption and cigarette smoking (p<0.05).

MeSH terms

Adult
Alcoholism / diagnosis
Alcoholism / genetics*
Humans
Karyotyping
Lymphocytes / ultrastructure
Male
Sister Chromatid Exchange*
Smoking / genetics*