Assignment of the human TYRP (brown) locus to chromosome region 9p23 by nonradioactive in situ hybridization

Genomics. 1992 May;13(1):227-9. doi: 10.1016/0888-7543(92)90228-k.


The TYRP (brown) locus determines pigmentation and coat color in the mouse. The human homolog of the TYRP locus has been recently identified and shown to encode a 75-kDa transmembrane melanosomal glycoprotein called gp75. The gp75 glycoprotein is homologous to tyrosinase, an enzyme involved in the synthesis of melanin, forming a family of tyrosinase-related proteins. A genomic clone of human gp75 was used to map the human TYRP locus to chromosome 9, region 9p23, by nonradioactive fluorescent in situ hybridization. Specificity of hybridization was tested with a genomic fragment of human tyrosinase that mapped to a distinct site on 11q21. The 9p region has been reported to be nonrandomly altered in human melanoma, suggesting a role for the region near the TYRP locus in melanocyte transformation.

Publication types

  • Research Support, Non-U.S. Gov't
  • Research Support, U.S. Gov't, P.H.S.

MeSH terms

  • Chromosomes, Human, Pair 9*
  • Fluorescence
  • Humans
  • Melanoma / genetics
  • Membrane Glycoproteins / genetics*
  • Monophenol Monooxygenase / genetics*
  • Nucleic Acid Hybridization
  • Pigmentation / genetics*
  • Sensitivity and Specificity
  • Sequence Homology, Nucleic Acid


  • Membrane Glycoproteins
  • Monophenol Monooxygenase