Pharmacological and surgical therapy for primary postpartum hemorrhage

Curr Pharm Des. 2005;11(6):759-73. doi: 10.2174/1381612053381882.


Early postpartum hemorrhage remains a significant cause of maternal morbidity and mortality. Postpartum hemorrhage is most commonly due to uterine atony and often responds to medical treatments such as administration of uterotonic drugs, alone or in combination with uterine massage or bimanual compression. As the incidence of cesarean section continues to rise, the problem of placenta previa and accreta is likely to become more common. For first-line management of postpartum hemorrhage adequate blood and fluid replacement is mandatory. In recent years new therapeutic measures to control the bleeding have gained attention. Although, these newer therapies focus on avoiding the need for emergency hysterectomy and preservation of reproductive function, reports of subsequent pregnancies are still scarce. Established management options are shortly reviewed and novel medical and surgical treatments are more extensively discussed.

Publication types

  • Review

MeSH terms

  • Adult
  • Embolization, Therapeutic
  • Female
  • Humans
  • Postpartum Hemorrhage / drug therapy
  • Postpartum Hemorrhage / etiology
  • Postpartum Hemorrhage / prevention & control
  • Postpartum Hemorrhage / surgery
  • Postpartum Hemorrhage / therapy*
  • Pregnancy