Randomized controlled trial of olanzapine in the treatment of cognitions in anorexia nervosa

Australas Psychiatry. 2005 Mar;13(1):72-5. doi: 10.1080/j.1440-1665.2004.02154.x.


Objective: Recovery from anorexia nervosa is confounded by intrusive anorectic cognitions and rituals. It has been observed that olanzapine, an atypical antipsychotic, can reduce this anorexic rumination. A pilot study was designed to test the effectiveness of olanzapine in this role.

Methods: A randomized trial of olanzapine versus chlorpromazine, with anorexic rumination as the primary outcome, was conducted. Of the 26 patients who presented, 15 were randomized in a balanced block design, eight to olanzapine and seven to chlorpromazine.

Results: Only the olanzapine group had a significant reduction in the degree of rumination.

Conclusion: Olanzapine may be of benefit in anorexia nervosa by causing a reduction in anorexic rumination.

Publication types

  • Clinical Trial
  • Randomized Controlled Trial

MeSH terms

  • Adult
  • Anorexia Nervosa / complications*
  • Antipsychotic Agents / administration & dosage
  • Antipsychotic Agents / therapeutic use*
  • Benzodiazepines / administration & dosage
  • Benzodiazepines / therapeutic use*
  • Chlorpromazine / therapeutic use
  • Cognition Disorders / diagnosis
  • Cognition Disorders / drug therapy*
  • Cognition Disorders / etiology*
  • Drug Administration Schedule
  • Female
  • Humans
  • Male
  • Olanzapine


  • Antipsychotic Agents
  • Benzodiazepines
  • Olanzapine
  • Chlorpromazine