Dual functions of murine gammadelta cells in inflammation and autoimmunity in coxsackievirus B3-induced myocarditis: role of Vgamma1+ and Vgamma4+ cells

Microbes Infect. 2005 Mar;7(3):537-43. doi: 10.1016/j.micinf.2004.12.011. Epub 2005 Feb 5.


Coxsackieviruses are a cause of clinical myocarditis. Both virus replication and host defense mechanisms, including virus-induced autoimmunity, mediate heart injury and cardiac dysfunction. Vgamma4+ cells kill infected cardiocytes and virus-specific CD4+ Th2 cells through Fas-dependent apoptosis and CD1d. The CD4+ Th1 response is necessary for activation of the autoimmune CD8+ T cells, which kill uninfected cardiocytes through perforin-dependent mechanisms.

Publication types

  • Review

MeSH terms

  • Animals
  • Autoimmunity / immunology*
  • Cardiomyopathy, Dilated / immunology
  • Cardiomyopathy, Dilated / virology
  • Coxsackievirus Infections / immunology*
  • Enterovirus B, Human*
  • Mice
  • Myocarditis / immunology*
  • Myocarditis / virology*
  • Signal Transduction
  • T-Lymphocyte Subsets / immunology*