Linking Rap to cell adhesion

Curr Opin Cell Biol. 2005 Apr;17(2):123-8. doi: 10.1016/


The small GTPase Rap1 is involved in several aspects of cell adhesion, including integrin-mediated cell adhesion and cadherin-mediated cell junction formation. Recently, several effector proteins for Rap1 have been identified providing a clear link between Rap1 and actin dynamics. Furthermore, evidence is accumulating that Rap1 functions in the spatial and temporal control of cell polarity.

Publication types

  • Research Support, Non-U.S. Gov't
  • Review

MeSH terms

  • Actin Cytoskeleton / metabolism*
  • Animals
  • Cell Adhesion / physiology
  • Cell Membrane / metabolism*
  • Cell Polarity / physiology*
  • Humans
  • Models, Biological
  • Second Messenger Systems / physiology
  • Signal Transduction / physiology*
  • rap1 GTP-Binding Proteins / genetics
  • rap1 GTP-Binding Proteins / metabolism*


  • rap1 GTP-Binding Proteins