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, 85 (4), 472-82

Two Novel Genes, Gpr113, Which Encodes a Family 2 G-protein-coupled Receptor, and Trcg1, Are Selectively Expressed in Taste Receptor Cells

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Two Novel Genes, Gpr113, Which Encodes a Family 2 G-protein-coupled Receptor, and Trcg1, Are Selectively Expressed in Taste Receptor Cells

Nelson D LopezJimenez et al. Genomics.

Abstract

To identify genes important for taste receptor cell function, we analyzed the sequences and expression patterns of clones isolated from a mouse taste receptor cell-enriched cDNA library. Here, we report the analyses of two novel genes, Gpr113 and Trcg1. Gpr113 encodes a G-protein-coupled receptor belonging to family 2B, members of which are characterized by having long N-terminal, extracellular domains. The predicted N-terminal extracellular domain of GPR113 contains 696 amino acids with two functional domains, a peptide hormone-binding domain and a G-protein-coupled receptor proteolytic site. Expression analyses indicate that Gpr113 expression is highly restricted to a subset of taste receptor cells. TRCG1 is also selectively expressed in a subset of taste receptor cells. Trcg1 is alternatively spliced and encodes Trcg1 isoforms of 209 and 825 amino acids. BLAST searches of genomic sequences indicate that a putative homolog of Trcg1 resides on human chromosome 15q22.

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