Transcriptional activation: mediator can act after preinitiation complex formation

Mol Cell. 2005 Mar 18;17(6):752-4. doi: 10.1016/j.molcel.2005.03.002.

Abstract

The Mediator complex connects transcriptional activators bound at enhancers with RNA polymerase (Pol) II. demonstrate that Mediator also has an important role in transcriptional activation after recruitment of the Pol II machinery to promoters.

Publication types

  • Comment
  • Review

MeSH terms

  • Acetylation
  • Chromatin / metabolism
  • Histones / metabolism
  • Immediate-Early Proteins / metabolism
  • MAP Kinase Signaling System
  • Methylation
  • Promoter Regions, Genetic / genetics*
  • RNA Polymerase II / physiology*
  • Transcription Factors / metabolism
  • Transcriptional Activation*

Substances

  • Chromatin
  • Histones
  • Immediate-Early Proteins
  • Transcription Factors
  • RNA Polymerase II