Do elderly systolic heart failure patients benefit from beta blockers to the same extent as the non-elderly? Meta-analysis of >12,000 patients in large-scale clinical trials

Am J Cardiol. 2005 Apr 1;95(7):896-8. doi: 10.1016/j.amjcard.2004.11.052.


A meta-analysis of all-cause mortality data involving elderly and non-elderly chronic heart failure patients from 5 completed beta-blocker trials revealed that elderly and non-elderly chronic heart failure patients derived considerable prognostic benefit from beta-blocker therapy without a statistically significant difference in mortality reduction between the 2 groups.

Publication types

  • Meta-Analysis

MeSH terms

  • Adrenergic beta-Antagonists / therapeutic use*
  • Age Factors
  • Aged
  • Heart Failure / drug therapy*
  • Heart Failure / mortality
  • Humans
  • Middle Aged
  • Systole
  • Treatment Outcome


  • Adrenergic beta-Antagonists