Effectiveness of bupropion for smoking cessation during pregnancy

J Addict Dis. 2005;24(2):19-23. doi: 10.1300/J069v24n02_02.


Gestational smoking has been established as a risk to the fetus. However, many pregnant smokers are unable to quit due to the highly addictive nature of nicotine. Nicotine replacement therapy has failed in several studies in pregnant women. In a prospective matched, controlled observational study, of 22 pregnant smokers receiving bupropion, 10 (45%) ceased smoking, as compared to 3 (14%) of 22 controls (P = 0.047). Bupropion appears to be effective for smoking cessation therapy during pregnancy.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Adult
  • Bupropion / therapeutic use*
  • Dopamine Uptake Inhibitors / therapeutic use*
  • Female
  • Humans
  • Pregnancy
  • Pregnancy Complications / drug therapy*
  • Severity of Illness Index
  • Smoking Cessation / methods*
  • Smoking Prevention*
  • Tobacco Use Disorder / drug therapy*


  • Dopamine Uptake Inhibitors
  • Bupropion