Green coffee bean extract improves human vasoreactivity

Hypertens Res. 2004 Oct;27(10):731-7. doi: 10.1291/hypres.27.731.


Our previous study revealed the antihypertensive effects of green coffee bean extract (GCE) ingestion in spontaneously hypertensive rats. We suggested that this antihypertensive action was due to the fact that GCE contains chlorogenic acid (CQA) as a major phenolic compound, and CQA in turn contains ferulic acid as a metabolic component that acts on nitric oxide (NO) derived from the vascular endothelium. In this study, the effects of GCE on blood vessels were evaluated in healthy males. The subjects were 20 healthy males with reduced vasodilation responses measured by strain gauge plethysmograms (SPG) to ischemic reactive hyperemia. Of the 20 subjects, 10 (mean age, 37.2 years) ingested a test drink containing GCE (CQA: 140 mg/day), and the other 10 (mean age, 34.8 years) ingested a placebo drink for 4 months. During the ingestion period, SPG, pulse wave velocity (PWV), and serum biochemical parameters were measured, and acceleration plethysmograms (APG) were taken. The reactive hyperemia ratio (RHR) in the test drink group began to increase after ingestion for 1 month and was significantly higher (p <0.05) than that in the placebo group after ingestion for 3 months and 4 months. In addition, after ingestion for 4 months, the test drink group showed a significant decrease (p <0.01) in the plasma total homocysteine level compared with the pre-ingestion level. However, there were no significant differences in PWV or APG between the test drink group and the placebo drink group. The improvement in RHR after ingestion of a drink containing GCE suggested an improvement in vasoreactivity by this component.

Publication types

  • Clinical Trial
  • Controlled Clinical Trial

MeSH terms

  • Adult
  • Arteries / physiopathology
  • Blood Pressure / drug effects
  • Blood Vessels / drug effects*
  • Coffea / chemistry*
  • Compliance
  • Homocysteine / blood
  • Humans
  • Hyperemia / etiology
  • Hyperemia / physiopathology
  • Ischemia / complications
  • Male
  • Plant Extracts / pharmacology*
  • Reference Values
  • Seeds / chemistry*
  • Vasodilation
  • Vasomotor System / drug effects*


  • Plant Extracts
  • Homocysteine