JetPeel (Tav-Tech Ltd., Yehud, Israel) is a new device for cosmetic resurfacing of the facial skin. It uses a new technology of a 2-phase stream that creates a jet composed of gas (oxygen) and microdroplets of fluid (saline) accelerated to supersonic velocities. This jet impacts the skin, causing gentle and accurate cosmetic peeling. Our preclinical and clinical experience with the JetPeel for rejuvenation of the face is presented. In a group of 50 patients, we found the JetPeel technology to be a safe and effective new tool for the usual indications for facial peeling. It was most useful and effective for perioral peel. JetPeel can be used in combination with other resurfacing modalities such as chemical peeling or laser. Further investigation is needed to explore other applications of this technology, such as using different combinations of gases and fluids and transdermal transfer of medication dissolved in the peeling jet.