Naturally arising Foxp3-expressing CD25+CD4+ regulatory T cells in immunological tolerance to self and non-self

Nat Immunol. 2005 Apr;6(4):345-52. doi: 10.1038/ni1178.


Naturally arising CD25(+)CD4(+) regulatory T cells actively maintain immunological self-tolerance. Deficiency in or dysfunction of these cells can be a cause of autoimmune disease. A reduction in their number or function can also elicit tumor immunity, whereas their antigen-specific population expansion can establish transplantation tolerance. They are therefore a good target for designing ways to induce or abrogate immunological tolerance to self and non-self antigens.

Publication types

  • Research Support, Non-U.S. Gov't
  • Review

MeSH terms

  • Animals
  • Antigens, CD
  • Antigens, Differentiation / immunology
  • Autoimmune Diseases / immunology
  • CD4 Antigens / immunology*
  • CTLA-4 Antigen
  • DNA-Binding Proteins / immunology*
  • Forkhead Transcription Factors
  • Humans
  • Lymphocyte Activation
  • Neoplasms / immunology
  • Receptors, Interleukin-2 / immunology*
  • Self Tolerance / immunology*
  • T-Lymphocytes / immunology*
  • Thymus Gland / immunology
  • Transplantation Immunology


  • Antigens, CD
  • Antigens, Differentiation
  • CD4 Antigens
  • CTLA-4 Antigen
  • CTLA4 protein, human
  • DNA-Binding Proteins
  • FOXP3 protein, human
  • Forkhead Transcription Factors
  • Receptors, Interleukin-2