Complex Trait Mapping in Isolated Populations: Are Specific Statistical Methods Required?

Eur J Hum Genet. 2005 Jun;13(6):698-706. doi: 10.1038/sj.ejhg.5201400.


In this paper, we review the statistical methods that can be used in isolated populations to map genes involved in complex diseases. Our intention is to highlight the fact that if the features of population isolates may help in the identification of susceptibility factors for complex traits, the choice and design of methods for statistical analysis in these populations deserve particular care. We show that methods designed for outbred samples are generally not appropriate for isolated populations and could lead to false conclusions.

Publication types

  • Research Support, Non-U.S. Gov't
  • Review

MeSH terms

  • Chromosome Mapping*
  • Genetic Linkage
  • Genetic Predisposition to Disease*
  • Genetics, Population / methods*
  • Humans
  • Inbreeding
  • Pedigree
  • Research Design