Nogo expression in muscle correlates with amyotrophic lateral sclerosis severity

Ann Neurol. 2005 Apr;57(4):553-6. doi: 10.1002/ana.20420.


Nogo, a protein inhibiting axonal regeneration, exhibits a characteristic isoform-specific pattern of expression in skeletal muscle of transgenic mice and patients with amyotrophic lateral sclerosis. Here, the increased levels of Nogo-A or Nogo-B in muscle biopsies of 15 amyotrophic lateral sclerosis patients significantly correlated with the severity of clinical disability and with the degree of muscle fiber atrophy. Nogo-A immunoreactivity was observed selectively in atrophic slow-twitch type I fibers. These results suggest that Nogo expression in muscle is a marker of amyotrophic lateral sclerosis severity.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Adult
  • Aged
  • Aged, 80 and over
  • Amyotrophic Lateral Sclerosis / metabolism*
  • Biomarkers / analysis*
  • Blotting, Western
  • Female
  • Humans
  • Immunohistochemistry
  • Male
  • Middle Aged
  • Muscle Fibers, Slow-Twitch / metabolism
  • Muscle, Skeletal / metabolism*
  • Myelin Proteins / biosynthesis*
  • Nogo Proteins
  • Severity of Illness Index


  • Biomarkers
  • Myelin Proteins
  • Nogo Proteins
  • RTN4 protein, human
  • Rtn4 protein, mouse