[Evaluating biological tolerance of PMMA, heparin-modified PMMA and hydrogel intraocular lenses using slit lamp microscopy]

Klin Monbl Augenheilkd. 1992 Feb;200(2):95-100. doi: 10.1055/s-2008-1045719.
[Article in German]


In order to find a difference in the biocompatibility of different IOL-materials we examined the lens-surface of poly(methylmetacrylate)-(PMMA-), heparin surface-modified PMMA-(HSM-PMMA-) and hydrogel-IOLs in a prospective study by specular microscopy. Documentation consisted of cellular reaction, precipitates on the lens-surface and irregularities of the IOL-material. Early postoperative on HSM-PMMA and hydrogel-IOLs there were fewer fibroblast-like cells as compared to PMMA-IOLs. In the later postoperative period foreign body giant cells were seen on PMMA-IOLs in 26.6%, on HSM-PMMA and hydrogel-IOLs in less than 10% of the cases. In cases with increased postoperative inflammation or contact between uveal tissue and lens-surface we found more cells and in a higher percentage. Concerning precipitates on the surface and material irregularities we also found lens-specific differences. Clinical results were satisfactory for all lens-types.

Publication types

  • Comparative Study

MeSH terms

  • Aged
  • Fibroblasts / pathology
  • Foreign-Body Reaction / pathology*
  • Giant Cells, Foreign-Body / pathology
  • Heparin*
  • Humans
  • Hydrogel, Polyethylene Glycol Dimethacrylate
  • Lenses, Intraocular*
  • Materials Testing*
  • Methylmethacrylates*
  • Microscopy
  • Polyethylene Glycols*
  • Postoperative Complications / pathology*
  • Surface Properties


  • Methylmethacrylates
  • Hydrogel, Polyethylene Glycol Dimethacrylate
  • Polyethylene Glycols
  • Heparin