Renal failure after percutaneous coronary intervention is associated with high mortality

Catheter Cardiovasc Interv. 2005 Apr;64(4):442-8. doi: 10.1002/ccd.20316.


Renal failure is a marker of poor outcome in the general population. Renal failure after percutaneous coronary artery intervention (PCI) is associated with an increased hazard of in-hospital mortality. We hypothesized that post-PCI renal insufficiency would be a predictor of long-term mortality in patients undergoing PCI who survive for over 30 days after the procedure. A retrospective analysis was conducted from a registry of 9,067 patients undergoing PCI at our center from 1997 to 2001. A rise in creatinine by 1 mg/dl from baseline was defined as post-PCI renal insufficiency. Vital status was assessed using Social Security Death Index. There were a total of 996 deaths over a mean follow-up period of 3.2 years. In a multivariate analysis, history of recent acute myocardial infarction, older age, insulin-dependent diabetes, baseline creatinine greater than 1.5 mg/dl, and presence of mitral regurgitation were associated with post-PCI renal insufficiency. Developing post-PCI renal insufficiency was associated with a 4.31-fold hazard of mortality in univariate analysis and a 1.77-fold hazard after adjustment for known predictors of mortality after PCI. The 1-year survival in patients with renal failure was 70.3% +/- 3.91%, compared to a survival of 93.6% +/- 0.27% in those without any post-PCI renal insufficiency (P < 0.0001). Acute renal insufficiency after PCI is a strong and independent predictor of long-term mortality in patients who survived for 30 days after the procedure.

Publication types

  • Comparative Study

MeSH terms

  • Acute Kidney Injury / etiology*
  • Acute Kidney Injury / mortality*
  • Acute Kidney Injury / physiopathology
  • Age Distribution
  • Aged
  • Aged, 80 and over
  • Angioplasty, Balloon, Coronary / adverse effects*
  • Angioplasty, Balloon, Coronary / methods
  • Cause of Death*
  • Coronary Angiography / methods
  • Coronary Disease / diagnostic imaging
  • Coronary Disease / therapy*
  • Female
  • Follow-Up Studies
  • Humans
  • Incidence
  • Kidney Function Tests
  • Male
  • Middle Aged
  • Multivariate Analysis
  • Probability
  • Proportional Hazards Models
  • Registries
  • Retrospective Studies
  • Severity of Illness Index
  • Sex Distribution
  • Stents*