The B7/CD28 costimulatory family in autoimmunity

Immunol Rev. 2005 Apr;204:128-43. doi: 10.1111/j.0105-2896.2005.00242.x.

Abstract

Host defense is dependent on the appropriate induction of immune responses. A central concept in immunology is the ability of the immune system to differentiate foreign from self-antigens. The failure of the immune response to recognize foreign pathogens can result in infection and disease in the host. The inappropriate response of the immune system to self-antigens is equally problematic, leading to autoimmune disease. Central and peripheral tolerance mechanisms control self-reactive T-cell responses and protect peripheral tissues from autoimmune attack. This review examines the roles of B7/CD28 family members, which can augment or antagonize T-cell receptor signaling, in the regulation of central and peripheral T-cell tolerance. We also discuss how B7/CD28 pathways influence both T-cell-intrinsic and -extrinsic mechanisms of regulation.

Publication types

  • Research Support, Non-U.S. Gov't
  • Research Support, U.S. Gov't, P.H.S.
  • Review

MeSH terms

  • Animals
  • Autoimmunity / genetics
  • Autoimmunity / immunology*
  • B7-1 Antigen / genetics
  • B7-1 Antigen / immunology*
  • CD28 Antigens / genetics
  • CD28 Antigens / immunology*
  • Dendritic Cells / immunology
  • Immune Tolerance / immunology
  • T-Lymphocytes / cytology
  • T-Lymphocytes / immunology

Substances

  • B7-1 Antigen
  • CD28 Antigens