Skip to main page content
Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
Review
, 307 (5717), 1915-20

Host-bacterial Mutualism in the Human Intestine

Affiliations
Review

Host-bacterial Mutualism in the Human Intestine

Fredrik Bäckhed et al. Science.

Abstract

The distal human intestine represents an anaerobic bioreactor programmed with an enormous population of bacteria, dominated by relatively few divisions that are highly diverse at the strain/subspecies level. This microbiota and its collective genomes (microbiome) provide us with genetic and metabolic attributes we have not been required to evolve on our own, including the ability to harvest otherwise inaccessible nutrients. New studies are revealing how the gut microbiota has coevolved with us and how it manipulates and complements our biology in ways that are mutually beneficial. We are also starting to understand how certain keystone members of the microbiota operate to maintain the stability and functional adaptability of this microbial organ.

Similar articles

  • Human Gut Microbiota and Bifidobacteria: From Composition to Functionality
    F Turroni et al. Antonie Van Leeuwenhoek 94 (1), 35-50. PMID 18338233. - Review
    The human gut is the home of an estimated 10(18) bacterial cells, many of which are uncharacterized or unculturable. Novel culture-independent approaches have revealed th …
  • Ecological and Evolutionary Forces Shaping Microbial Diversity in the Human Intestine
    RE Ley et al. Cell 124 (4), 837-48. PMID 16497592. - Review
    The human gut is populated with as many as 100 trillion cells, whose collective genome, the microbiome, is a reflection of evolutionary selection pressures acting at the …
  • Honor Thy Symbionts
    J Xu et al. Proc Natl Acad Sci U S A 100 (18), 10452-9. PMID 12923294.
    Our intestine is the site of an extraordinarily complex and dynamic environmentally transmitted consortial symbiosis. The molecular foundations of beneficial symbiotic ho …
  • Gut Microflora as a Target for Energy and Metabolic Homeostasis
    PD Cani et al. Curr Opin Clin Nutr Metab Care 10 (6), 729-34. PMID 18089955. - Review
    Gut microflora may play an even more important role in maintaining human health than previously thought. The literature provides new evidence that the increased prevalenc …
  • Gastrointestinal Microbiology Enters the Metagenomics Era
    DN Frank et al. Curr Opin Gastroenterol 24 (1), 4-10. PMID 18043225. - Review
    Through technological and conceptual innovations in metagenomics, the complex microbial habitat of the human gastrointestinal tract is now amenable to detailed ecological …
See all similar articles

Cited by 1,292 PubMed Central articles

See all "Cited by" articles

Publication types

LinkOut - more resources

Feedback