Staging and grading of chronic gastritis

Hum Pathol. 2005 Mar;36(3):228-33. doi: 10.1016/j.humpath.2004.12.008.


Chronic gastritis is an inflammatory condition of the gastric mucosa that may include structural alterations of the glandular compartment. The semiquantitative scoring systems advocated in the Sydney Systems and the subsequent Atrophy Club Guidelines remain essential for the recognition of the spectrum of the lesions detectable in gastric inflammatory disease. Most practicing pathologists, however, find them too cumbersome to use in their routine diagnostic activities. In this article, we propose a reporting system for chronic gastritis in staging and grading. Staging would convey information on the topography and extension of the gastric atrophic changes, whereas grading should represent the semiquantitative assessment of the combined severity of both mononuclear and granulocytic inflammation. This system could offer gastroenterologists a more immediate perception of the overall condition of the gastric mucosa while also providing useful information about gastric cancer risk.

Publication types

  • Review

MeSH terms

  • Atrophy
  • Chronic Disease
  • Gastric Mucosa / pathology
  • Gastritis / classification
  • Gastritis / complications
  • Gastritis / pathology*
  • Humans
  • Phenotype
  • Pyloric Antrum / pathology
  • Risk Factors
  • Stomach Neoplasms