[Semax in prevention of disease progress and development of exacerbations in patients with cerebrovascular insufficiency]

Zh Nevrol Psikhiatr Im S S Korsakova. 2005;105(2):35-40.
[Article in Russian]

Abstract

One hundred and eighty-seven patients with different stages of cerebrovascular insufficiency (CI) have been examined. A diagnosis of CI was based on the results of neurological and neuropsychological study, ultrasonic dopplerography, rheo- and encephalography, electrocardiography, brain MRI and eyegrounds examination. Neurological scales were used for neurological status assessment and further data processing. The study aimed at evaluation of tolerability and clinical efficacy of the medication and complications in CI course. Semax treatment resulted in significant clinical improvement, stabilization of the disease progress and reduced a risk of stroke and transitory ischemic attacks in the disease course. The drug is featured by minor percent of side-effects and is well tolerated by patients, including those of older age groups.

Publication types

  • Comparative Study
  • Evaluation Study

MeSH terms

  • Adrenocorticotropic Hormone / administration & dosage
  • Adrenocorticotropic Hormone / adverse effects
  • Adrenocorticotropic Hormone / analogs & derivatives*
  • Adrenocorticotropic Hormone / therapeutic use*
  • Adult
  • Age Factors
  • Aged
  • Cerebrovascular Disorders / complications
  • Cerebrovascular Disorders / diagnosis
  • Cerebrovascular Disorders / diagnostic imaging
  • Cerebrovascular Disorders / drug therapy*
  • Cerebrovascular Disorders / prevention & control
  • Disease Progression
  • Electroencephalography
  • Female
  • Follow-Up Studies
  • Fundus Oculi
  • Geriatric Assessment
  • Humans
  • Hypertension / complications
  • Intracranial Arteriosclerosis / complications
  • Magnetic Resonance Imaging
  • Male
  • Middle Aged
  • Neuropsychological Tests
  • Nootropic Agents / administration & dosage
  • Nootropic Agents / adverse effects
  • Nootropic Agents / therapeutic use*
  • Peptide Fragments / administration & dosage
  • Peptide Fragments / adverse effects
  • Peptide Fragments / therapeutic use*
  • Personality Inventory
  • Risk Factors
  • Stroke / prevention & control
  • Time Factors
  • Treatment Outcome
  • Ultrasonography, Doppler, Transcranial

Substances

  • Nootropic Agents
  • Peptide Fragments
  • ACTH (4-7), Pro-Gly-Pro-
  • Adrenocorticotropic Hormone