Bacterial vaginosis: treatment with clindamycin cream versus oral metronidazole

Obstet Gynecol. 1992 Jun;79(6):1020-3.


In a randomized, double-blind study, 48 women with symptomatic bacterial vaginosis were assigned to receive either 5 g of 2% clindamycin vaginal cream daily or 500 mg metronidazole oral tablets twice a day for 7 days. After completion of therapy, there was no significant difference in cure rates (clindamycin 72% versus metronidazole 87%). One month later, 61% of the patients in each group were still cured. Adverse reactions were mild in both groups. We conclude that clindamycin cream is a safe, well tolerated, and effective alternative to oral metronidazole for treatment of bacterial vaginosis.

Publication types

  • Clinical Trial
  • Randomized Controlled Trial
  • Research Support, Non-U.S. Gov't

MeSH terms

  • Administration, Oral
  • Adult
  • Clindamycin / administration & dosage*
  • Clindamycin / adverse effects
  • Double-Blind Method
  • Female
  • Humans
  • Metronidazole / administration & dosage*
  • Metronidazole / adverse effects
  • Middle Aged
  • Prospective Studies
  • Vaginal Creams, Foams, and Jellies
  • Vaginosis, Bacterial / drug therapy*


  • Vaginal Creams, Foams, and Jellies
  • Metronidazole
  • Clindamycin