Levofloxacin and ciprofloxacin decrease procainamide and N-acetylprocainamide renal clearances

Antimicrob Agents Chemother. 2005 Apr;49(4):1649-51. doi: 10.1128/AAC.49.4.1649-1651.2005.

Abstract

Ten healthy adults participated in a randomized, crossover drug interaction study testing procainamide only, procainamide plus levofloxacin, and procainamide plus ciprofloxacin. During levofloxacin therapy, most procainamide and N-acetylprocainamide (NAPA) pharmacokinetic parameters, including decreased renal clearances and renal clearance/creatinine clearance ratios, changed (P < 0.05). During ciprofloxacin treatment, only procainamide and NAPA renal clearances decreased significantly.

Publication types

  • Clinical Trial
  • Randomized Controlled Trial

MeSH terms

  • Acecainide / pharmacokinetics*
  • Adult
  • Anti-Arrhythmia Agents / pharmacokinetics*
  • Anti-Bacterial Agents / pharmacokinetics*
  • Ciprofloxacin / pharmacokinetics*
  • Cross-Over Studies
  • Drug Interactions
  • Female
  • Humans
  • Kidney / drug effects
  • Kidney / metabolism*
  • Levofloxacin*
  • Male
  • Ofloxacin / pharmacokinetics*
  • Procainamide / pharmacokinetics*

Substances

  • Anti-Arrhythmia Agents
  • Anti-Bacterial Agents
  • Ciprofloxacin
  • Levofloxacin
  • Acecainide
  • Ofloxacin
  • Procainamide