Elevated IgG4 concentrations in serum of patients with Mikulicz's disease

Scand J Rheumatol. 2004;33(6):432-3. doi: 10.1080/03009740410006439.


Mikulicz's disease has recently been included within primary Sjögren's syndrome. It is a unique condition involving enlargement of the lacrimal and salivary glands, characterized by few autoimmune reactions. It is responsive to glucocorticoid treatment. Analysis of IgG fractions was performed in patients with Mikulicz's disease in order to determine the differences between Mikulicz's disease and Sjögren's syndrome. The study showed that serum IgG4 concentrations are elevated in patients with Mikulicz's disease, but not in those with Sjögren's syndrome.

Publication types

  • Comparative Study

MeSH terms

  • Aged
  • Biomarkers / blood
  • Diagnosis, Differential
  • Female
  • Glucocorticoids / therapeutic use
  • Humans
  • Immunoglobulin G / blood*
  • Male
  • Mikulicz' Disease / blood
  • Mikulicz' Disease / diagnosis*
  • Mikulicz' Disease / drug therapy
  • Prognosis
  • Risk Assessment
  • Sampling Studies
  • Severity of Illness Index
  • Sjogren's Syndrome / diagnosis*


  • Biomarkers
  • Glucocorticoids
  • Immunoglobulin G