Regulatory T cells and type 1 diabetes

Curr Diab Rep. 2005 Apr;5(2):104-9. doi: 10.1007/s11892-005-0036-x.


Regulatory T cells are now recognized as important mediators of self-tolerance and may mediate responses to immune therapy. The mechanisms of action of these cells are diverse, and some studies suggest that there may be defects in regulatory cells in patients with type 1 diabetes. These cells may be expanded by immune therapy, suggesting the possible development of adoptive immune therapy to transfer regulation with the cells.

Publication types

  • Research Support, N.I.H., Extramural
  • Research Support, U.S. Gov't, P.H.S.
  • Review

MeSH terms

  • Diabetes Mellitus, Type 1 / immunology*
  • Homeostasis / immunology
  • Humans
  • Immune Tolerance / immunology
  • Immunity, Innate
  • T-Lymphocytes / immunology*