Severe topiramate-associated hyperthermia resulting in persistent neurological dysfunction

Clin Neuropharmacol. 2005 Mar-Apr;28(2):94-5. doi: 10.1097/01.wnf.0000159957.95134.1b.


Topiramate has recently been reported to cause hyperthermia as a result of oligohydrosis, primarily in pediatric patients. All cases reported to date were clinically mild, without permanent systemic or neurologic dysfunction. We report a case of severe hyperthermia and subsequent ataxia and tremor in an adult treated with topiramate. To our knowledge, this is the first case of topiramate-associated hyperthermia to result in residual cerebellar and cognitive dysfunction.

Publication types

  • Case Reports

MeSH terms

  • Adult
  • Anticonvulsants / adverse effects*
  • Fever / etiology*
  • Fructose / adverse effects*
  • Fructose / analogs & derivatives*
  • Humans
  • Hypohidrosis
  • Male
  • Seizures / drug therapy
  • Topiramate


  • Anticonvulsants
  • Topiramate
  • Fructose