Role of afterload reduction in the prevention of late anthracycline cardiomyopathy

Pediatr Blood Cancer. 2005 Jun 15;44(7):607-13. doi: 10.1002/pbc.20351.


Afterload reduction is useful for treating and preventing adult congestive heart failure outside the realm of anthracycline toxicity. Afterload reducers are commonly used as treatment for acute heart failure associated with anthracyclines. However, the use of afterload reduction for the prevention of anthracycline associated late cardiomyopathy remains a controversial area, with strong opinions expressed concerning the potential risks and benefits of such an approach. This article will define "afterload" and the tools utilized to measure afterload. The study will then describe the theory for the use of afterload reduction in patients with anthracycline exposure who show signs of anthracycline cardiotoxicity, and will present data from the ACE-Inhibitor After Anthracyclines (AAA) Trial to help answer the question, "Should an afterload reducer be used to aid in preventing late anthracycline cardiotoxicity?" Finally, recommendations for future research will be presented.

Publication types

  • Research Support, N.I.H., Extramural
  • Research Support, U.S. Gov't, P.H.S.
  • Review

MeSH terms

  • Angiotensin-Converting Enzyme Inhibitors / therapeutic use*
  • Anthracyclines / adverse effects*
  • Cardiomyopathies / chemically induced*
  • Cardiomyopathies / diagnosis
  • Cardiomyopathies / prevention & control*
  • Forecasting
  • Guidelines as Topic
  • Humans
  • Neoplasms / drug therapy*


  • Angiotensin-Converting Enzyme Inhibitors
  • Anthracyclines