Abstract
A Ni/Pybox catalyst achieves the asymmetric cross-coupling of secondary alpha-bromo amides with organozinc reagents. The process tolerates a variety of functional groups and affords the desired product in good yield and in high enantiomeric excess.
Publication types
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Research Support, Non-U.S. Gov't
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Research Support, U.S. Gov't, Non-P.H.S.
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Research Support, U.S. Gov't, P.H.S.
MeSH terms
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Amides / chemical synthesis*
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Amides / chemistry
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Catalysis
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Hydrocarbons, Brominated / chemistry
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Nickel / chemistry
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Organometallic Compounds / chemistry*
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Stereoisomerism
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Zinc / chemistry*
Substances
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Amides
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Hydrocarbons, Brominated
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Organometallic Compounds
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Nickel
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Zinc